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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

Russia launched a major air attack early Thursday on Kyiv that included a rare strike on the city center, killing at least 21 people, wounding 48 and damaging European diplomatic offices.

After a yearlong search, Amazon announced Tuesday that it will divide its second headquarters between the Long Island City neighborhood in Queens and Arlington in Northern Virginia.

Experts believe Chinese leader Xi Jinping intends to bend, break or scrap informal succession rules. He is most opposed to a rule that could hinder his ability to designate his own successor.

The president intends to nominate Navy Rear Adm. Ronny Jackson, the White House physician, to lead the Department of Veterans Affairs.

Here are three big-picture takeaways after the Senate Judiciary Committee's release of more than 2,500 pages of transcripts, emails and other materials.

If a Democrat wins an Ohio special election, it would be the latest sign of alarm for Republicans ahead of November's midterm election. Progressives hope for more upset wins Tuesday night.

The White House has been strong against China in trade talks, but NPR and PBS Frontline found top advisers battled for more than a year over imposing billions of dollars in tariffs on Chinese imports.

Lightfoot is the city's first black female and openly gay mayor. After her swearing in, she laid out a plan to make Chicago "a city that families want to move to, not run away from."

The Senate is beginning its trial after the House voted to impeach President Trump. Here is what you need to know about what led up to this moment and what the president is accused of.